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A portion of patients with life-threatening COVID-19 pneumonia had inborn errors of TLR3- and IRF7-dependent type I IFN immunity.

News items for the week of Sept. 21, 2020. 

Avapritinib is sold by Blueprint Medicines as Ayvakit for the treatment of adults with unresectable or metastatic GIST harboring a PDGFRA exon 18 mutation.

Sequencing of ancient samples showed that Denisovan Y chromosomes split around 700,000 years ago from a lineage shared by Neanderthals and modern humans.

Both of the RT-PCR-based tests use healthcare provider-collected samples and may be used by any lab CLIA-certified to perform high-complexity tests.

With array and exome data, Australian investigators saw apparent ties between amelanotic/hypomelanotic melanoma and rare albinism gene changes.

The second EUA for a test that targets the ORF1a and N genes is for an automated version of a manual test that had been granted EUA in August.

In PNAS this week: similar muscle protein patterns across hypertrophic cardiomyopathy phenotypes, analysis of gene expression and brain anatomy in major depression, and more.

Promega will develop its microsatellite instability assay as a companion diagnostic for Incyte's anti-PD-1 drug candidate retifanlimab in endometrial cancer.

Into One System

A new initiative aims to move Australia's genome sequencing labs onto one system, the Sydney Morning Herald reports.

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Novavax has begun a phase III trial of its SARS-CoV-2 vaccine, according to the New York Times.

Vox reports that the Trump Administration may limit student visas for individuals from some countries to two years.

The governor of New York says the state will conduct its own review of any SARS-CoV-2 vaccine, NPR reports.

This week in Science: Neanderthal Y chromosomes replaced by Homo sapiens Y chromosomes, and more.