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Biodesix Inks $23M Debt Refinancing

NEW YORK (GenomeWeb) – Biodesix said today it has increased the size of its offering of Series G preferred shares in a follow-on sale, and has simultaneously entered a debt refinancing agreement with Innovatus Capital Partners for a $23 million term loan.

The company said it plans to use the additional capital to fund development of blood-based tests for guiding use of cancer immunotherapies, as well as to further the commercialization of its VeriStrat and GeneStrat lung cancer tests.

Biodesix also announced that Scott Hutton has joined the firm as chief operating officer. Hutton previously served as senior vice president and general manager of Spectranetics. Before that he was vice president and general manager of Medtronic's neurosurgery unit.

The Scan

Study Points to Tuberculosis Protection by Gaucher Disease Mutation

A mutation linked to Gaucher disease in the Ashkenazi Jewish population appears to boost Mycobacterium tuberculosis resistance in a zebrafish model of the lysosomal storage condition, a new PNAS study finds.

SpliceVault Portal Provides Look at RNA Splicing Changes Linked to Genetic Variants

The portal, described in Nature Genetics, houses variant-related messenger RNA splicing insights drawn from RNA sequencing data in nearly 335,700 samples — a set known as the 300K-RNA resource.

Automated Sequencing Pipeline Appears to Allow Rapid SARS-CoV-2 Lineage Detection in Nevada Study

Researchers in the Journal of Molecular Diagnostics describe and assess a Clear Labs Dx automated workflow, sequencing, and bioinformatic analysis method for quickly identifying SARS-CoV-2 lineages.

UK Team Presents Genetic, Epigenetic Sequencing Method

Using enzymatic DNA preparation steps, researchers in Nature Biotechnology develop a strategy for sequencing DNA, along with 5-methylcytosine and 5-hydroxymethylcytosine, on existing sequencers.