Skip to main content

Twist Bioscience, Vivlion Partner on Guide RNA Libraries for CRISPR Applications

NEW YORK – Twist Bioscience said on Wednesday it is partnering with Vivlion to generate guide RNA, or gRNA, libraries for use in CRISPR studies.

Under the terms of the deal, Vivlion will purchase Twist's oligo pools to generate and sell precision CRISPR libraries for functional genomics research. Vivlion's proprietary 3Cs technology bypasses standard cloning methods such as PCR amplification, allowing direct conversion of Twist's oligo pools into gRNA libraries that maintain uniformity, including the generation of multiplexed and fixed-pair libraries.

"Twist is the ideal partner for the oligos needed for our CRISPR libraries. Their market expertise and ability to quickly generate large quantities of long, high-quality oligonucleotides provides Vivlion with a ready-made platform to amplify our impact," Vivlion CEO Ivan Dikic said in a statement. "The combined technologies have the potential to accelerate genomic research and enable scientists to decipher the function of genes more quickly."

Germany-based Vivlion is a spinout from Goethe University Frankfurt am Main offering gene editing reagents and screening services for the global R&D market.

In December 2020, Vivlion obtained a non-exclusive license to ERS Genomics' CRISPR-Cas9 patent portfolio.


The Scan

Call to Look Again

More than a dozen researchers penned a letter in Science saying a previous investigation into the origin of SARS-CoV-2 did not give theories equal consideration.

Not Always Trusted

In a new poll, slightly more than half of US adults have a great deal or quite a lot of trust in the Centers for Disease Control and Prevention, the Hill reports.

Identified Decades Later

A genetic genealogy approach has identified "Christy Crystal Creek," the New York Times reports.

Science Papers Report on Splicing Enhancer, Point of Care Test for Sexual Transmitted Disease

In Science this week: a novel RNA structural element that acts as a splicing enhancer, and more.