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Top 10 Articles on GenomeWeb in 2016

NEW YORK (GenomeWeb) – A busy year in the genomic research tools and molecular diagnostic industries was marked by some significant acquisitions, lawsuits, and uncertainty over regulations and reimbursement for clinical products.

Among the most-read articles on the GenomeWeb site for the year were those tracking patent litigation in the sequencing space, updates on the FDA's plans for lab-developed tests and companion diagnostics, and the acquisition of a pioneer in the microarray space. Below is a list of the 10 articles that gained the most interest among our readers in 2016.

1) Mother's Negligence Suit Against Quest's Athena Could Broadly Impact Genetic Testing Labs

2) Illumina Sues Qiagen for Patent Infringement

3) Illumina Unveils Mini Targeted Sequencer, Semiconductor Sequencing Project at JP Morgan Conference

4) Roche Terminates Dx Technology Development Agreement With Pacific Biosciences

5) FDA Holding Off on Finalizing Regulatory Guidance for Lab-Developed Tests

6) Class Action Lawsuit Against Illumina Alleges Firm and Two Officials Misled Investors

7) Former Affymetrix Execs Offer to Buy Company in Alternative to Thermo Fisher Deal

8) FDA Releases Draft Guidance Outlining Principles of Drug/Diagnostic Codevelopment

9) Illumina and Oxford Nanopore Settle Patent Infringement Lawsuit

10) Thermo Fisher to Acquire Affymetrix for $1.3B

The Scan

Machine Learning Helps ID Molecular Mechanisms of Pancreatic Islet Beta Cell Subtypes in Type 2 Diabetes

The approach helps overcome limitations of previous studies that had investigated the molecular mechanisms of pancreatic islet beta cells, the authors write in their Nature Genetics paper.

Culture-Based Methods, Shotgun Sequencing Reveal Transmission of Bifidobacterium Strains From Mothers to Infants

In a Nature Communications study, culture-based approaches along with shotgun sequencing give a better picture of the microbial strains transmitted from mothers to infants.

Microbial Communities Can Help Trees Adapt to Changing Climates

Tree seedlings that were inoculated with microbes from dry, warm, or cold sites could better survive drought, heat, and cold stress, according to a study in Science.

A Combination of Genetics and Environment Causes Cleft Lip

In a study published in Nature Communications, researchers investigate what combination of genetic and environmental factors come into play to cause cleft lip/palate.