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Thermo Fisher Scientific, Cellenion Partner to Develop Workflows for Single-Cell Proteomics Analysis

NEW YORK – Thermo Fisher Scientific and Cellenion said on Monday that they have signed a comarketing agreement to develop workflows for single-cell, mass spectrometry-based proteomics analyses.

Under the terms of the partnership, the companies will combine Cellenion's CellenOne single-cell isolation system and ProteoChip consumable with Thermo Fisher's TMT multiplexing technologies and Orbitrap mass spectrometers to build workflows for single-cell isolation and automated sample preparation through to mass spec-based proteomics analysis on single cells. 

Financial terms of the deal were not disclosed.

The CellenOne system combines image-based single cell isolation and nanoliter dispensing to perform every step of sample preparation using a single device, and its ProteoChip 12*16 is a dedicated consumable for automated and loss-less sample preparation prior to multiplexed single-cell proteomics analyses, Cellenion said. Thermo Scientific Orbitrap mass spectrometers, in combination with enhanced sensitivity and throughput by multiplexing cells with TMT isobaric labelling, allow for more proteins per cell to be delivered.

"This partnership will accelerate development of novel solutions for sample preparation prior to multiplexed single-cell proteomics analyses," Cellenion Managing Director Guilhem Tourniaire said in a statement. "By automating sample preparation, we hope to encourage the adoption of these revolutionary methods, bring a new dimension to biology, and ultimately, contribute to the future of health." 

Separately on Monday, Thermo Fisher said it was extending its existing comarketing agreement with Biognosys to provide laboratories performing high-throughput plasma analysis with new and streamlined instruments, kits, and software to enable efficient and accurate workflows at scale.

The companies first signed the comarketing agreement for Thermo Fisher's Orbitrap mass spectrometers and Biognosys' Spectronaut Pulsar software in June 2017.

The PQ500 Reference Peptide Kit from Biognosys is now able to quantify more than 500 proteins in human plasma and serum samples as part of the SureQuant IS-PRM workflow, enabled only with the Thermo Scientific Orbitrap Exploris 480 mass spectrometer, Thermo Fisher said. Biognosys' SpectroDive software extends research applications to targeted proteomics enabling automated mass spectrometry method set-up, signal processing, and analysis of targeted experiments, such as the SureQuant IS-PRM workflow.

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