Skip to main content
Premium Trial:

Request an Annual Quote

Syapse Expands FDA Collaboration to Include COVID-19 Impact on Cancer Care

NEW YORK – Syapse said Tuesday that it has expanded its existing research collaboration with the U.S. Food and Drug Administration's Oncology Center of Excellence to include, among other things, research into the impact of COVID-19 on cancer care.

San Francisco-based Syapse has been helping the FDA's Oncology Center for Excellence incorporate real-world evidence into regulatory decision-making. The partners have been investigating ways to derive real-world data from multiple sources, including electronic health records, genomic tests, and cancer registries, and well as to understand how patients respond to therapies outside of the context of clinical trials.

"One of our goals is to reduce the burden of lengthy clinical trials on cancer patients and clinical researchers, and we are optimistic that the use of real-world data will help us address important questions more rapidly today, and increasingly so in the future," FDA Principal Deputy Commissioner Amy Abernethy said in a statement. Abernethy added that the agency is "learning quickly how sophisticated analyses of real-world data can provide rapid insights into COVID-19."

Syapse CMO Thomas Brown highlighted the importance of patient history in determining the efficacy of drugs. "Understanding how a patient’s medical history influences their treatment outcomes in a real-world setting is critical for clinicians, researchers, and regulatory agencies to appropriately weigh the risk-benefit profile of a drug for a given patient," he said.

Syapse earlier this year raised $30 million in new equity investments to support its collaborations and its application of precision medicine in guiding real-world outcomes.

The Scan

Machine Learning Helps ID Molecular Mechanisms of Pancreatic Islet Beta Cell Subtypes in Type 2 Diabetes

The approach helps overcome limitations of previous studies that had investigated the molecular mechanisms of pancreatic islet beta cells, the authors write in their Nature Genetics paper.

Culture-Based Methods, Shotgun Sequencing Reveal Transmission of Bifidobacterium Strains From Mothers to Infants

In a Nature Communications study, culture-based approaches along with shotgun sequencing give a better picture of the microbial strains transmitted from mothers to infants.

Microbial Communities Can Help Trees Adapt to Changing Climates

Tree seedlings that were inoculated with microbes from dry, warm, or cold sites could better survive drought, heat, and cold stress, according to a study in Science.

A Combination of Genetics and Environment Causes Cleft Lip

In a study published in Nature Communications, researchers investigate what combination of genetic and environmental factors come into play to cause cleft lip/palate.