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Sophia Genetics, AstraZeneca Team on In-House HRD Testing in Ovarian Cancer

NEW YORK – Sophia Genetics said Thursday that it is collaborating with AstraZeneca to help European laboratories and research institutions conduct in-house testing for homologous recombination deficiency in ovarian cancer.

The collaboration will center around Sophia's newly released, deep learning-based application on its Data-Driven Medicine (DDM) platform for HRD detection. The app, also introduced Thursday, combines identification of HRD-causing mutations with analysis of HRD-induced genomic instability across tumor genomes to inform cancer research. 

"Providing laboratories with innovative solutions to enable locally delivered HRD testing is critically important, particularly in settings such as advanced ovarian cancer, where approximately half of all newly diagnosed patients have HRD-positive tumors," Kristina Rodnikova, senior VP of global oncology diagnostics at AstraZeneca, said in a statement. 

Switzerland-based Sophia said that its new DDM HRD product decentralizes HRD testing of tumor samples, enabling end users to access Sophia's genomic analysis while retaining ownership of their data.

"Our Sophia DDM HRD solution will provide researchers and other healthcare professionals with a decentralized approach to fully integrated HRD testing, enabling the HRD status of more advanced ovarian cancer cases to be determined without reliance on send-out testing solutions," Sophia cofounder and CEO Jurgi Camblong said.

The Scan

Pig Organ Transplants Considered

The Wall Street Journal reports that the US Food and Drug Administration may soon allow clinical trials that involve transplanting pig organs into humans.

'Poo-Bank' Proposal

Harvard Medical School researchers suggest people should bank stool samples when they are young to transplant when they later develop age-related diseases.

Spurred to Develop Again

New Scientist reports that researchers may have uncovered why about 60 percent of in vitro fertilization embryos stop developing.

Science Papers Examine Breast Milk Cell Populations, Cerebral Cortex Cellular Diversity, Micronesia Population History

In Science this week: unique cell populations found within breast milk, 100 transcriptionally distinct cell populations uncovered in the cerebral cortex, and more.