Twist Bioscience FlexPrep Ultra-High Throughput Library Preparation Kit
Twist Bioscience has launched its FlexPrep Ultra-High Throughput Library Preparation Kits, designed to accelerate the adoption of next-generation sequencing by microarray users in population and agricultural genomics. The kit improves upon standard enzymatic fragmentation library preparation methods with the introduction of a novel "Normalization by Ligation" (NBL) technology, which eliminates the need for time-consuming upfront sample quantitation, and enables sample pooling and multiplexing early in the workflow, Twist said. Researchers can run up to 1,152 samples in a single 96-well plate sequencing run and, compared to processing samples individually, FlexPrep reduces consumables use 12-fold and reduces the number of pipette tips from more than 17,000 to less than 4,000, the company noted. The FlexPrep UHT kit can also be paired with Twist's custom target enrichment panels for tunable and uniform coverage of genomic regions of interest. In addition, Twist said it is collaborating with Gencove to offer analysis solutions to FlexPrep UHT customers to understand their data and deliver fast, cost-effective, and accurate genotyping results.
Nonacus Galeas uPCR ESR1 Assay
Nonacus has launched a research-use-only qPCR kit to detect ESR1 mutations. The Galeas uPCR ESR1 kit is an ultrasensitive qPCR assay developed to detect eleven mutations in the ESR1 gene known to be associated with resistance to endocrine therapy, a common treatment for certain types of breast cancer. uPCR is a novel method developed by Nonacus that increases the sensitivity and specificity of mutation detection for qPCR but does not require an investment in special equipment, the company said.
Inocras MRDVision
Inocras has launched MRDVision, a minimal residual disease test that combines the firm's whole-genome sequencing cancer profiling bioinformatics platform, CancerVision, with Ultima Genomics' ppmSeq sequencing technology for analyzing circulating tumor DNA from blood. According to Inocras, the limit of detection is one in a million. The test is available for research immediatedly and will be available for clinical use in 2025.
DNAStar Lasergene 18
DNAStar has released Lasergene 18, an update to its Lasergene software package. The new version includes an update to GenVision Pro, a genome browser, that can now visualize and analyze genomic data across multiple samples. In addition, it features a diploid phasing algorithm for analyzing long-read datasets the size of the human genomes. GenVision Pro now also integrates variant analysis including variant filtering, displays of phased variants, and the ability to create and compare custom SNP sets. Further, Lasergene 18 has a new gene set enrichment analysis (GSEA) workflow, a specialized version of the RNA-seq differential expression workflow that focuses on groups of genes with commonalities. With Lasergene 18, customers can now also create secure local sequence databases for local BLAST searches, use Golden Gate virtual cloning, and access the IQ Tree algorithm for making phylogenetic trees.
GeneCentric Therapeutics ExpressCT Liquid Biopsy Platform
GeneCentric Therapeutics has launched the ExpressCT (Expression Signatures Through Circulating Tumor Signals) liquid biopsy platform, a development tool that adapts RNA-based gene expression signatures to cell-free DNA liquid biopsy assays in order to provide insights beyond DNA mutations. The firm has so far developed liquid biopsy cfDNA signature tests for pancreatic, lung, breast, and colon cancer and is partnering with other firms with suitable liquid biopsy assays to use the ExpressCT technology.
Parse Biosciences GigaLab
Parse Biosciences has launched its GigaLab, a service offering for large-scale single-cell projects. GigaLab provides Parse's Evercode single-cell technology for projects scaling to 10 million cells or more, with a current capacity of 2.5 billion cells per year. The service could address large-scale drug and perturbation screens, dataset generation for generative AI models, and atlasing for population studies.
Geneyx/Ocean Genomics SVDuo Software
Geneyx and Ocean Genomics have released SVDuo software. Available on the Geneyx Analysis platform for research and clinical applications and integrated into Ocean's TxomeAI, the software combines DNA and RNA analysis to enhance the detection of genomic variants, advancing disease diagnosis and the discovery of biomarkers and drug targets.
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