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New Products Posted to GenomeWeb: Thermo Fisher, Blackhawk Genomics, Biotium, More

Thermo Fisher Scientific Applied Biosystems QuantStudio 7 Pro Dx Real-Time PCR System

Thermo Fisher Scientific has launched the Applied Biosystems QuantStudio 7 Pro Dx Real-Time PCR System, a standalone qPCR platform that the company said is versatile, highly expandable, and easy to use. Designed to support in vitro diagnostic applications and the development of molecular diagnostic assays, the QuantStudio 7 Pro Dx system has sensitivity down to 1.5-fold in singleplex reactions and 10 logarithmic units of linear dynamic range. The platform supports interchangeable 96-well and 384-well blocks and automation compatibility, and for molecular laboratories developing and running their own tests, there are embedded regulatory controls to support traceability and reduce the risk of unauthorized use or potential misuse.

Other key system features include: security, auditing, and e-signature functionalities to assist in compliance with regulatory requirements and support multiple clients; software designed to guide users through workflow steps for test development or IVDs; the ability to create and manage assay definition files (ADFs) for a specific assay, panel, or test that incorporate all of the qPCR setup and analysis parameters required for a particular assay; a small footprint that doesn't require an attached computer, with a graphical user interface that enables end-to end workflows from the touchscreen; a six-color, decoupled OptiFlex filter system with bright white LED; hands-free functionality to enable the performance basic operations using voice commands; and smart support and smart help to report issues or request instrument services to reduce downtime. The system also uses up to 54 percent less material, generates 91 percent less waste during calibration, and uses up to 26 percent less energy than comparable instruments, the company said.

The US Food and Drug Administration has listed the QuantStudio 7 Pro Dx Real-Time PCR System as a class II medical device, Thermo Fisher added.


Blackhawk Genomics HerediSeq, PanSeq

Blackhawk Genomics has launched two genomic analysis kits, HerediSeq and PanSeq, designed to detect structural variants and elucidate difficult-to-characterize genomic regions using long-read sequencing. Both assays use CRISPR/Cas9 technology to enrich specific genomic regions prior to sequencing, without the need for amplification.

HerediSeq chemistry resolves deletions and duplications, repetitive regions and pseudogenes, allowing for easy and accurate identification of germline structural variants in genes associated with the increased risk of hereditary cancer and cardiac diseases as well as those relevant in carrier screening applications. PanSeq uses targeted enrichment for rapid detection of microbial, fungal, and viral species, plus treatment resistance markers.

Currently, three HerediSeq kits are available targeting cancer, cardiac diseases, and carrier screening content. Up to 24 samples can be sequenced in a single flow cell or run, and sample preparation takes less than a day. Each kit can process 96 samples. PanSeq kits can process 96 samples, all in a single run, with data available in less than a day from sample receipt.


Biotium EvaRuby Dye for qPCR and HRM

Biotium has introduced its EvaRuby Dye for qPCR and HRM (high-resolution melting). This spectrally unique red fluorescent intercalating dye can be used to expand multiplexing options for probe-based qPCR. It is compatible with approximately 470 nm excitation and 610 nm emission filters. Its excitation is by the same green/blue channel as EvaGreen Dye, and detection is in the orange (JUN or ROX) channel. As a result, it has minimal cross-talk in standard probe detection channels and enables the combination of dye-based and probe-based qPCR in a single reaction, the company said. In addition, the dye is validated for HRM analysis and may be used as an internal control for probe-based qPCR to detect non-specific amplification that goes undetected by target-specific probes, Biotium added.


For more new products and services, please visit the New Products page on our website.