Swift Biosciences Swift 2S Sonic DNA Library Kit
Swift Biosciences has released the Swift S2 Sonic DNA Library kit for next-generation sequencing of sheared DNA. The sample preparation kit is available in two configurations, for PCR indexing and for PCR-free indexing by ligation. It is compatible with Swift's Normalase technology and requires two hours of sample handling time.
The kits can be used for targeted hybridization capture with panels from Swift, Integrated DNA Technologies, and Twist Bioscience. The Swift HiFi Polymerase Master Mix supplied in the kits is suitable for pre-hybridization PCR to produce yields of 500 ng or greater, from as low as 1 ng DNA input.
The 96 reaction Swift 2S Sonic DNA library kit has a list price of $2,150.
Meridian Bioscience Inhibitor-Resistant qPCR Chemistries
Meridian Bioscience launched two novel inhibitor-resistant qPCR chemistries for the detection of DNA and RNA molecules directly from liquid biopsy samples without needing nucleic acid extraction. The mixes can be used to develop cancer diagnostic tests and workflows requiring fast turnaround times while ensuring high specificity.
The mixes can tolerate high levels of inhibitors in blood, allowing for improvements in limit of detection by adding more sample in the reaction, Meridian said. Studies have shown superior sensitivity compared to other mixes, even in samples with difficult conditions, such as 20 percent blood, the company added.
Establishing molecular tests to detect circulating cancer biomarkers can be difficult due to sample variability and inhibitory properties of the specimen, issues Meridian says its two new mixes can help fix.
Pacific Biosciences Sequel IIe System, SMRT Link 10 Software
Pacific Biosciences has launched the Sequel IIe system. This updated version of the Sequel II single-molecule sequencing instrument is optimized to generate the firm's HiFi reads directly. The Sequel IIe eliminates the need for post-processing and can reduce secondary analysis time by up to 70 percent, with up to a 90 percent reduction in file transfer and data storage costs.
PacBio has also added new tools to its SMRT Link software to enable complete workflow integration on Amazon Web Services cloud computing and a new genome assembly analysis application for generating reference-quality de novo assemblies from HiFi reads.
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