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New Products Posted to GenomeWeb: Roche, Jumpcode Genomics, Mikrogen, More

Roche Avenio Tumor Tissue Comprehensive Genomic Profiling Kit

Roche has launched its Avenio Tumor Tissue Comprehensive Genomic Profiling (CGP) Kit for research use. The jointly developed project from Roche and Foundation Medicine delivers information about complex genomic signatures, including tumor mutational burden, microsatellite instability, and loss of heterozygosity, in addition to a comprehensive genomic panel. It provides an end-to-end next-generation sequencing workflow, including DNA extraction and library preparation, and delivers results by the FoundationOne Analysis Platform via Avenio Connect.

The kit's gene panel is drawn from the FoundationOne companion diagnostic panel, analyzing 324 cancer-related genes across four main classes of genomic alterations and genomic signatures. It is configured to run 24 samples with results in five days on Illumina's NextSeq 500/550 RUO and NextSeq 550 Dx System in research mode.

The kit is intended for laboratories to use in house and will launch in Europe, North America, Asia, and South America.

Jumpcode Genomics CRISPRclean rRNA Depletion Kits

Jumpcode Genomics has launched two new kits for ribosomal RNA depletion. The CRISPRclean Stranded Total RNA Prep kit with rRNA depletion offers unbiased depletion and library preparation for RNA sequencing. The CRISPRclean Plus kit depletes over 200 bacteria species and human rRNA sequences to enable identification of lower-expressed transcripts.

Mikrogen T-Track SARS-CoV-2 Assay

Mikrogen, a Neuried, Germany-based developer of genetically manufactured in vitro diagnostics, has introduced its research-use-only T-Track SARS-CoV-2 assay to determine T-cell-mediated immune responses. The new RT-qPCR assays detect the mRNA expression of several specific marker cytokines simultaneously. The assays require about 3 ml of heparin blood/patient, are conducive to partial automation and intermediate storage of samples, and have shown a high sensitivity in the early infection phase, the company said.

For more new products and services, please visit the New Products page on our website.

The Scan

Cell Signaling Pathway Identified as Metastasis Suppressor

A new study in Nature homes in on the STING pathway as a suppressor of metastasis in a mouse model of lung cancer.

Using Bees to Gain Insights into Urban Microbiomes

As bees buzz around, they pick up debris that provides insight into the metagenome of their surroundings, researchers report in Environmental Microbiome.

Age, Genetic Risk Tied to Blood Lipid Changes in New Study

A study appearing in JAMA Network Open suggests strategies to address high lipid levels should focus on individuals with high genetic risk and at specific ages.

Study Examines Insights Gained by Adjunct Trio RNA Sequencing in Complex Pediatric Disease Cases

Researchers in AJHG explore the diagnostic utility of adding parent-child RNA-seq to genome sequencing in dozens of families with complex, undiagnosed genetic disease.