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New Products Posted to GenomeWeb: Qiagen, BioEcho, Twist Bioscience, More

Qiagen QuantiFeron SARS-CoV-2 RUO Assay

Qiagen has launched the QuantiFeron SARS-CoV-2 RUO assay to detect T-cell responses of the human immune system to the SARS-CoV-2 virus. The assay, which is for research use only, could help researchers gain new information on immunity levels and disease progression. Studies have suggested that T cell response to the virus declines much more slowly than antibody response, and that it provides a reliable indication of how severe the course of illness will be in infected patients.

The new product will initially comprise a 'starter set' and a 'monitor direct' package for separate or combined research use. Both are made up of QuantiFeron blood collection tubes with a proprietary stimulation principle, and the QuantiFeron detection system to measure the resulting interferon-gamma.


BioEcho EchoLution for Viral RNA and DNA Extraction

Köln, Germany-based BioEcho has launched the new EchoLution viral RNA and DNA extraction kit. The firm's reverse chromatography-based single-step extraction kits are available in 48- and 96-well formats and can extract nucleic acids in approximately two minutes.

The kit has been validated for SARS-CoV-2 RNA detection from nasopharyngeal samples.


Twist Bioscience Clonal-Ready Gene Fragments

Twist Bioscience has launched clonal-ready gene fragments. The synthetic DNA products are available with and without adapters and can be used to build constructs. Potential applications include cloning, gene and protein expression, pathway and enzyme engineering, and enzyme optimization.

Gene fragments begin as oligonucleotides, are annealed, and amplified to produce double-stranded DNA fragments. They are error-corrected in an enzymatic reaction. The error rate is 1 in 5,300 base pairs; for shorter oligonucleotides between 300 and 800 base pairs long, the error rate drops to 1 in 6,200.

For more new products and services, please visit the New Products page on our website.

The Scan

Study Points to Tuberculosis Protection by Gaucher Disease Mutation

A mutation linked to Gaucher disease in the Ashkenazi Jewish population appears to boost Mycobacterium tuberculosis resistance in a zebrafish model of the lysosomal storage condition, a new PNAS study finds.

SpliceVault Portal Provides Look at RNA Splicing Changes Linked to Genetic Variants

The portal, described in Nature Genetics, houses variant-related messenger RNA splicing insights drawn from RNA sequencing data in nearly 335,700 samples — a set known as the 300K-RNA resource.

Automated Sequencing Pipeline Appears to Allow Rapid SARS-CoV-2 Lineage Detection in Nevada Study

Researchers in the Journal of Molecular Diagnostics describe and assess a Clear Labs Dx automated workflow, sequencing, and bioinformatic analysis method for quickly identifying SARS-CoV-2 lineages.

UK Team Presents Genetic, Epigenetic Sequencing Method

Using enzymatic DNA preparation steps, researchers in Nature Biotechnology develop a strategy for sequencing DNA, along with 5-methylcytosine and 5-hydroxymethylcytosine, on existing sequencers.