Pacific Biosciences HiFi Sequencing and SMRT Link v10.1 Updates
Pacific Biosciences has launched an updated HiFi sequencing workflow and the Sequel II and IIe software v10.1.
The new workflow increases the number of HiFi reads at or above 99.9 percent accuracy for whole-genome sequencing applications. It includes a new library preparation protocol enabling a threefold reduction in DNA input and new consumables, including the SMRTbell enzyme clean up kit 2.0, Sequel II Primer v5, and polymerase binding kit 2.2.
The updated software includes on-instrument workflow improvements that simplify run setup, especially for multiplexed applications, including IsoSeq, and a SARS-CoV-2 analysis application that uses HiFi reads.
Paragon Genomics SARS-CoV-2 Emerging Variant Panel Add-On
Paragon Genomics has launched its SARS-CoV-2 Emerging Variant Panel Add-on. The test is designed to be used with existing CleanPlex SARS-CoV-2 panels to ensure robust genome coverage for variant calling and identification. The firm said the kit's primers can be implemented into CleanPlex library prep workflows with minimal disruption.
Bio-Techne DNAscope Assays
Bio-Techne has expanded its Advanced Cell Diagnostics RNAscope technology with release of its new DNAscope assays. DNAscope, Bio-Techne's chromogenic DNA in situ hybridization (ISH) technology, employs a double-z probe design and the signal amplification system of RNAscope to enable rapid and flexible probe development for DNA targets and the visualization of targets in formalin-fixed paraffin-embedded tissues. The firm's RNAscope technology is an ISH assay that enables visualization of single-molecule gene expression with single-cell resolution directly in intact cells and tissues.
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