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New Products Posted to GenomeWeb: Pacific Biosciences, Paragon Genomics, Bio-Techne, More

Pacific Biosciences HiFi Sequencing and SMRT Link v10.1 Updates

Pacific Biosciences has launched an updated HiFi sequencing workflow and the Sequel II and IIe software v10.1.

The new workflow increases the number of HiFi reads at or above 99.9 percent accuracy for whole-genome sequencing applications. It includes a new library preparation protocol enabling a threefold reduction in DNA input and new consumables, including the SMRTbell enzyme clean up kit 2.0, Sequel II Primer v5, and polymerase binding kit 2.2.

The updated software includes on-instrument workflow improvements that simplify run setup, especially for multiplexed applications, including IsoSeq, and a SARS-CoV-2 analysis application that uses HiFi reads.


Paragon Genomics SARS-CoV-2 Emerging Variant Panel Add-On

Paragon Genomics has launched its SARS-CoV-2 Emerging Variant Panel Add-on. The test is designed to be used with existing CleanPlex SARS-CoV-2 panels to ensure robust genome coverage for variant calling and identification. The firm said the kit's primers can be implemented into CleanPlex library prep workflows with minimal disruption.


Bio-Techne DNAscope Assays

Bio-Techne has expanded its Advanced Cell Diagnostics RNAscope technology with release of its new DNAscope assays. DNAscope, Bio-Techne's chromogenic DNA in situ hybridization (ISH) technology, employs a double-z probe design and the signal amplification system of RNAscope to enable rapid and flexible probe development for DNA targets and the visualization of targets in formalin-fixed paraffin-embedded tissues. The firm's RNAscope technology is an ISH assay that enables visualization of single-molecule gene expression with single-cell resolution directly in intact cells and tissues.

For more new products and services, please visit the New Products page on our website.

The Scan

Enzyme Involved in Lipid Metabolism Linked to Mutational Signatures

In Nature Genetics, a Wellcome Sanger Institute-led team found that APOBEC1 may contribute to the development of the SBS2 and SBS13 mutational signatures in the small intestine.

Family Genetic Risk Score Linked to Diagnostic Trajectory in Psychiatric Disorders

Researchers in JAMA Psychiatry find ties between high or low family genetic risk scores and diagnostic stability or change in four major psychiatric disorders over time.

Study Questions Existence of Fetal Microbiome

A study appearing in Nature this week suggests that the reported fetal microbiome might be the result of sample contamination.

Fruit Fly Study Explores Gut Microbiome Effects on Circadian Rhythm

With gut microbiome and gene expression experiments, researchers in PNAS see signs that the microbiome contributes to circadian rhythm synchronicity and stability in fruit flies.