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New Products Posted to GenomeWeb: Natera, Qiagen, New England Biolabs, More

Natera Prospera Heart

Natera has launched its Prospera Heart transplant assessment test for heart transplant recipients. The Prospera test uses Natera's core SNP-based massively multiplexed PCR technology to identify allograft rejection noninvasively and with high precision and accuracy, without the need for prior donor or recipient genotyping. The test works by measuring the fraction of donor-derived cell-free DNA in the recipient's blood. It may be used by physicians considering the diagnosis of active rejection, helping to rule in or out this condition when evaluating the need for diagnostic testing or the results of an invasive biopsy.

The Prospera test has been clinically and analytically validated for performance regardless of donor relatedness, rejection type, and clinical presentation, Natera said.


New England Biolabs WarmStart Fluorescent LAMP/RT-LAMP Kit and Master Mix

New England Biolabs has released the WarmStart Multi-Purpose LAMP/RT-LAMP 2X Master Mix and the WarmStart Fluorescent LAMP/RT-LAMP Kit. The products allow researchers to perform efficient, high-throughput detection of nucleic acids using a variety of amplification detection methods. The master mix has dUTP and UDG for carryover prevention, can be used with highly buffered and acidic samples, and supports multiple detection methods including turbidity detection and non-pH-based colorimetric detection. The kit is a fully buffered Multi-Purpose LAMP/RT-LAMP 2X Master Mix and a fluorescent dye in one package.


Qiagen PreAnalytix PaxGene Saliva Collector

Qiagen recently launched the PreAnalytix PAXGene Saliva Collector, a noninvasive and painless sample collection method containing a preservation solution that stabilizes DNA levels in human saliva samples by protecting the DNA from degradation and inhibiting bacterial growth throughout storage. The device was developed by PreAnalytix, a joint venture between Qiagen and Becton Dickinson. One initial area of application is sample collection for SARS-CoV-2 research, Qiagen said. In addition to DNA stabilization, SARS-CoV-2-derived RNA copy numbers are preserved when saliva is collected in the PAXGene Saliva Collector. SARS-CoV-2 RNA present in a saliva sample is stabilized for at least four days at 20° C. While the PAXGene Saliva Collector stabilizes SARS-CoV-2 particles for detection and quantification, it efficiently inactivates the capability of the virus to infect and replicate itself in a cell culture model, Qiagen said.


For more new products and services, please visit the New Products page on our website.

The Scan

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By following pregnancy outcomes for women with RT-PCR-confirmed Zika virus infections, researchers saw in Lancet Regional Health congenital abnormalities in roughly one-third of live-born children.

Team Presents Benchmark Study of RNA Classification Tools

With more than 135 transcriptomic datasets, researchers tested two dozen coding and non-coding RNA classification tools, establishing a set of potentially misclassified transcripts, as they report in Nucleic Acids Research.

Breast Cancer Risk Related to Pathogenic BRCA1 Mutation May Be Modified by Repeats

Several variable number tandem repeats appear to impact breast cancer risk and age at diagnosis in almost 350 individuals carrying a risky Ashkenazi Jewish BRCA1 founder mutation.