Lucid Diagnostics EsoGuard Esophageal DNA Test
PAVmed's Lucid Diagnostics subsidiary has launched its EsoGuard Esophageal DNA Test as a laboratory-developed test after completing CLIA/CAP certification of the test. EsoGuard is a DNA test designed to facilitate the diagnosis of Barrett's esophagus and related precursors to esophageal adenocarcinoma.
EsoGuard LDT is performed on cells which are noninvasively sampled from the distal esophageal lining and shipped in a custom preservative solution to the ResearchDx facility in Irvine, California, where the DNA is immediately extracted. The DNA is then subjected to bisulfite conversion, PCR amplification, and next-generation sequencing to determine the methylation status of 31 sites on the vimentin and cyclinA1 genes, the company said. A bioinformatic algorithm is used to calculate the percentage of DNA molecules in which a proportion of methylated sites on either gene exceeds a certain threshold, delivering a positive or negative result.
A positive result has been associated with the presence of non-dysplastic Barrett's esophagus, dysplastic Barrett's esophagus, or esophageal adenocarcinoma, PAVmed added.
SpeeDx ResistancePlus MG FleXible
SpeeDx has launched the ResistancePlus MG FleXible for the GeneXpert System in Europe. The test detects Mycoplasma genitalium and markers associated with azithromycin resistance. It is now available in France and the UK, to be followed by the rest of the EU, Australia, and New Zealand. Cepheid is the exclusive distribution partner of the test through its FleXible Cartridge program for the GeneXpert System.
BioIVT NGS Services
BioIVT has launched next-generation sequencing services. The services include target mutation and subject cohort identification, human tissue procurement, sample and library preparation, sequencing, bioinformatics, and project design and management. The firm is offering both standard and custom services for assay validation as well as exploratory research.
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