Skip to main content
Premium Trial:

Request an Annual Quote

Molecular Loop Acquires Inversion Probe Tech From Invitae

NEW YORK (GenomeWeb) – Molecular Loop Biosolutions, a new startup focused on  sample prep and data analysis for next-generation DNA sequencing, said today that it has acquired from Invitae a molecular inversion probe-based technology initially developed by Good Start Genetics.

According to Molecular Loop, the intellectual property portfolio offers a streamlined process for producing high-quality variant and copy number calls from genomic DNA.

Greg Porreca, Molecular Loop's founder and CEO, first worked with the inversion probe technology as a co-founder of Good Start, which Invitae acquired in 2017.

According to Eric Boyden, Molecular Loop's head of R&D, the approach is simpler than hybrid capture technologies, but functions at a higher throughput than PCR amplification. It involves a "highly optimized tiling probe design" that is robust to allele dropout, as well as automated chemistry, error correction, and sample multiplexing that is resistant to index-swapping, the company said.

Financial and other terms of the deal with Invitae were not disclosed.

The Scan

Self-Reported Hearing Loss in Older Adults Begins Very Early in Life, Study Says

A JAMA Otolaryngology — Head & Neck Surgery study says polygenic risk scores associated with hearing loss in older adults is also associated with hearing decline in younger groups.

Genome-Wide Analysis Sheds Light on Genetics of ADHD

A genome-wide association study meta-analysis of attention-deficit hyperactivity disorder appearing in Nature Genetics links 76 genes to risk of having the disorder.

MicroRNA Cotargeting Linked to Lupus

A mouse-based study appearing in BMC Biology implicates two microRNAs with overlapping target sites in lupus.

Enzyme Involved in Lipid Metabolism Linked to Mutational Signatures

In Nature Genetics, a Wellcome Sanger Institute-led team found that APOBEC1 may contribute to the development of the SBS2 and SBS13 mutational signatures in the small intestine.