Skip to main content
Premium Trial:

Request an Annual Quote

DNA Script Exclusively Licenses Modified DNA Printing Technology From Baseclick

NEW YORK – DNA Script, a company developing benchtop DNA synthesis technology, today announced an exclusive licensing agreement for Baseclick's chemistry for printing modified DNA.

So-called "Click" chemistry allows dyes, quenchers, proteins, sugars and other modifications to be added to biomolecules, including nucleic acids. The terms of the agreement allow DNA Script to sell reagent kits with this technology, enabling customers to modify nucleic acids printed on DNA Script's Syntax benchtop system. Financial and other details were not disclosed.

"We see the use of Baseclick‐enabled oligo modification as a key element to enable broad use of enzymatically synthesized nucleic acids," Thomas Ybert, CEO and cofounder of DNA Script, said in a statement. "This exclusive license will help DNA Script strengthen its unique IP portfolio in the field."

"By enabling high-quality oligo labeling inside of our enzyme‐powered systems, we are improving de novo nucleic acid synthesis performance compared to current technologies," Ybert added. "In particular, we expect the combined offering to be game changing for diagnostic assay developers, who presently wait for weeks to secure what we can print in hours when powered by Baseclick's technology."

Click chemistry was developed by researchers at the Scripps Research Institute and published in 2001. Baseclick, a spinout from Ludwig Maximilians University in Munich and joint venture with German multinational chemical company BASF, holds a worldwide license covering use of click chemistry in nucleic acids.

In January, Paris-based DNA Script announced a $1.6 million deal with the French Defense Innovation Agency to build a platform for synthesizing qPCR probes. The company has raised over $100 million to date.

The Scan

Open Pediatric Brain Tumor Atlas Team Introduces Genomic Data Collection, Analytical Tools

A study in Cell Genomics outlines open-source methods being used to analyze and translate whole-genome, exome, and RNA sequence data from the Pediatric Brain Tumor Atlas.

Neurological Outcomes Linked to Innate Immune Features After Cardiac Arrest

Researchers reporting in Med dig into immune features found a few hours after cardiac arrest that correspond with neurological outcomes.

Mouse Study Finds Circadian Rhythm-Related Gene Expression Changes Linked to Sleep Apnea

A paper in PLOS Biology reveals tissue-specific circadian rhythm and gene expression patterns in an intermittent hypoxia-based mouse model of obstructive sleep apnea.

Polygenic Risk Score to Predict Preeclampsia, Gestational Hypertension in Pregnant Women

Researchers in Nature Medicine provide new mechanistic insights into the development of hypertensive disorders of pregnancy, which may help develop therapeutics.