Skip to main content
Premium Trial:

Request an Annual Quote

Codexis, Molecular Assemblies Ink Enzyme Engineering Collaboration Agreement

NEW YORK – Protein engineering company Codexis and Molecular Assemblies, a developer of enzymatic DNA synthesis technology, said on Tuesday that they will collaborate to engineer enzymes for improved and cost-effective DNA synthesis.

Under the terms of the agreement, Redwood City, California-based Codexis will purchase $1 million in Molecular Assemblies' Series A preferred stock, and Codexis President and CEO John Nicols will join Molecular Assemblies' board of directors. Codexis is also eligible to earn additional Series A preferred stock, including success-based milestones, which is expected to accumulate to an ownership stake in Molecular Assemblies in excess of 10 percent, the companies said.

Codexis will apply its CodeEvolver platform technology to improve the DNA polymerase enzymes that are needed for enzymatic DNA synthesis. The CodeEvolver protein engineering technology enables the rapid development of highly optimized proteins. San Diego-based Molecular Assemblies will combine its chemistries with Codexis' enzymes to drive the enzymatic synthesis process to commercialization.

"At Codexis, we are firm believers in the future-shaping potential of enzymatic DNA synthesis," Nicols said in a statement. "As we researched potential partners, we identified Molecular Assemblies as a pioneer in this field with a strong team and an industry-leading intellectual property position. Significant enzyme improvements from today's standards are required to reach technical and economic viability, improvements we believe only our CodeEvolver technology has the potential to achieve."

Molecular Assemblies President and CEO Michael Kamdar also noted that sustainable, scalable, cost-effective, and on-demand DNA production has applications in a broad range of industries, including synthetic biology, therapeutics, agriculture, and DNA data storage.

The Scan

Self-Reported Hearing Loss in Older Adults Begins Very Early in Life, Study Says

A JAMA Otolaryngology — Head & Neck Surgery study says polygenic risk scores associated with hearing loss in older adults is also associated with hearing decline in younger groups.

Genome-Wide Analysis Sheds Light on Genetics of ADHD

A genome-wide association study meta-analysis of attention-deficit hyperactivity disorder appearing in Nature Genetics links 76 genes to risk of having the disorder.

MicroRNA Cotargeting Linked to Lupus

A mouse-based study appearing in BMC Biology implicates two microRNAs with overlapping target sites in lupus.

Enzyme Involved in Lipid Metabolism Linked to Mutational Signatures

In Nature Genetics, a Wellcome Sanger Institute-led team found that APOBEC1 may contribute to the development of the SBS2 and SBS13 mutational signatures in the small intestine.