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In Brief This Week: Virginia Commonwealth University, Dovetail Genomics, Lucid Diagnostics, and More

NEW YORK – Virginia Commonwealth University Massey Cancer Center and Virginia State University this week received a $1.7 million team science grant from the National Cancer Institute to support their work reducing cancer disparities. The four-year grant will go toward a number of specific research projects, including an investigation into the genetics behind why Black Americans are more susceptible to liver and gastrointestinal cancers than white Americans. The funding, which represents the first time that a Virginia-based cancer center and a historically Black college or university have teamed up for this type of grant, will also support hands-on research opportunities for underrepresented science students.


Dovetail Genomics and wildlife conservation organization Revive & Restore this week announced a second project in the "A Genome for…" (AG4) program, sequencing a female wolverine nicknamed Laura. The new effort, "A Genome for Laura," will be crowdfunded by donations made by Dovetail on behalf of its service project customers. The genome assembly will become part of Revive & Restore's Wild Genomes collection, which will be open-source and freely available to the research and conservation community. The first AG4 project, "A Genome for Basuki," is now fully funded and will provide the research community with a high-quality genome assembly for the endangered Banggai cardinalfish of Indonesia, which went from discovery to near extinction in a matter of a few years due to high demand from the aquarium trade, Dovetail said.


Lucid Diagnostics said this week it has closed its initial public offering of 5 million shares of common stock at $14 per share, for gross proceeds of $70 million. The firm also granted the underwriters a 30-day option to purchase up to 750,000 additional shares of its stock at the IPO price, minus underwriting discounts and commissions. Cantor and Canaccord Genuity acted as the joint bookrunning managers for the offering, while BTIG and Needham acted as the co-lead managers.


Viome Life Sciences said this week that it has expanded an existing partnership with GlaxoSmithKline, focused on research and potential development of new therapeutic interventions in chronic diseases, including autoimmune diseases and cancers.

The new deal builds on a previously announced collaboration investigating the prevention of specific chronic diseases using Viome's microbiome analysis and artificial intelligence platform. Under the terms of the renewed agreement, the partners intend to conduct a clinical validation trial. Financial terms were not disclosed.


Biological Dynamics said this week that the US Food and Drug Administration has granted breakthrough device designation for its liquid biopsy assay, Exo-PDAC. The test is designed to provide early detection for pancreatic ductal adenocarcinoma by identifying exosomal biomarkers.

Exo-PDAC is the first assay to use Biological Dynamics' Verita platform, an alternating current electrokinetic-based technology, which the firm is exploring for cancer, Alzheimer’s disease, and infectious disease detection. The test requires a small amount of blood from patients, which is then analyzed with minimal sample preparation or processing.


Bioinformatics firm Deep Lens and health system Ocala Oncology/Florida Cancer Affiliates announced this week that they would expand their clinical research program using Deep Lens' artificial intelligence-based clinical trial matching solution, Viper. Ocala Oncology/Florida Cancer Affiliates is aiming to make more clinical trials available to its patients using Deep Lens' technology to automate identification of eligible patients. Viper will integrate with the health system's EMR to identify patients at diagnosis and integrate pathology feeds and molecular data feeds from Caris Life Sciences, Foundation Medicine, and Guardant Health. 


Digital health firm Everly Health this week announced the acquisition of Natalist, a women's health company that provides conception and pregnancy products for consumers. Specific terms of the all-cash transaction were not disclosed.

Natalist's products expand Everlywell's existing women's health offerings, which currently include at-home collection lab tests for menopause, fertility hormones, and sexual health, Everly Health said. In addition to its signature pregnancy and ovulation tests, Natalist's product suite supports women from pre-conception through pregnancy and includes tests, supplements, education, lubricants, and self-care items. Natalist is Everly Health's third acquisition this year.

In March, Everlywell acquired telehealth company PWNHealth and its subsidiary Home Access Health for an undisclosed amount, and subsequently formed Everly Health.


LumiraDx said this week that its SARS-CoV-2 Antigen test has received emergency use approval from India's Central Drugs Standard Control Organisation for use in that country. The test received Emergency Use Authorization from the US Food and Drug Administration in August 2020 and CE marking a month later. It detects antigen nucleocapsid protein from a nasal swab and provides results in 12 minutes, the London-based firm said.


Mesa Laboratories said this week that it has closed its $300 million acquisition of Agena Bioscience. Agena is expected to add between $63 million and $67 million of revenues to Mesa during the first 12 months of the deal, with high single digit organic revenue growth over the next several years, Mesa said. The company also noted that Agena is expected to add $3 million to $5 million of COVID-19-related revenues during the first year of the deal.


Verogen and Cellmark Forensic Services this week announced a partnership to offer next-generation sequencing-based forensic services. Cellmark has received ISO17025 accreditation from the UK Accreditation Service for NGS-based forensic DNA analysis. It will use Verogen's ForenSeq DNA Signature Prep Kit and the MiSeq FGx sequencing system.


Diagnostic testing company Plexision announced this week that it has received accreditation from the College of American Pathologists for its CLIA-certified reference laboratory in Pittsburgh. The lab performs cell-based blood tests for management of transplant rejection, infections in immunocompromised patients, and immune therapy in oncology. The firm’s tests can also be used to determine disease risk for several immunological disorders and develop personalized dosing recommendations.


In Brief This Week is a selection of news items that may be of interest to our readers but had not previously appeared on GenomeWeb.

The Scan

Germline-Targeting HIV Vaccine Shows Promise in Phase I Trial

A National Institutes of Health-led team reports in Science that a broadly neutralizing antibody HIV vaccine induced bnAb precursors in 97 percent of those given the vaccine.

Study Uncovers Genetic Mutation in Childhood Glaucoma

A study in the Journal of Clinical Investigation ties a heterozygous missense variant in thrombospondin 1 to childhood glaucoma.

Gene Co-Expression Database for Humans, Model Organisms Gets Update

GeneFriends has been updated to include gene and transcript co-expression networks based on RNA-seq data from 46,475 human and 34,322 mouse samples, a new paper in Nucleic Acids Research says.

New Study Investigates Genomics of Fanconi Anemia Repair Pathway in Cancer

A Rockefeller University team reports in Nature that FA repair deficiency leads to structural variants that can contribute to genomic instability.