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In Brief This Week: Qiagen, Mainz Biomed, Quest Diagnostics, Haystack Oncology, Becton Dickinson

NEW YORK – The US Federal Bureau of Investigation has approved Qiagen's next-generation sequencing-based ForenSeq Mainstay workflow. The high-throughput workflow is able to process 96 samples in one run and includes a kit targeting 52 autosomal and Y-STR DNA markers. It also includes the MiSeq FGx Sequencing System and the ForenSeq Mainstay Analysis Module. The FBI approval allows accredited forensic laboratories to process DNA casework samples and search resulting profiles against the US National DNA Index System database to help solve criminal investigations.

Mainz Biomed this week announced that Bioclinica has joined its network of laboratories offering Mainz's ColoAlert at-home colorectal cancer test. As a result, the test will become available to patients in Romania, where Bioclinica has 15 associated labs and 146 collection points in the country, according to Germany-based Mainz.

Quest Diagnostics said this week that it has completed its acquisition of Haystack Oncology. Haystack has developed a minimal-residual disease testing technology that uses circulating tumor DNA to aid in the detection of residual or reoccurring cancer and inform treatment decisions. Quest plans to incorporate Haystack's technology into a new blood-based clinical lab service for solid tumor cancers that will be available beginning in 2024. Quest originally announced in April that it was acquiring Haystack for up to $450 million in cash.

Becton Dickinson announced this week that it will sell its surgical instrumentation business to STERIS for $540 million. The divesture comprises V. Mueller, Snowden-Pencer, and Genesis branded products and three manufacturing facilities located in St. Louis, Cleveland, and Tuttlingen, Germany. Approximately 360 employees who support this platform will transfer to STERIS upon the completion of the transaction, which is expected to close within BD's fiscal year 2023, ending Sept. 30, pending satisfaction closing conditions and US Federal Trade Commission regulatory approval.

In Brief This Week is a selection of news items that may be of interest to our readers but had not previously appeared on GenomeWeb.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.