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In Brief This Week: Sigma-Aldrich; CLC Bio; Exiqon; Adaptive TCR; Evogene

NEW YORK (GenomeWeb News) – Investment bank Leerink Swann downgraded Sigma-Aldrich to Market Perform from Outperform and reduced its target share price on the firm to a range of between $66 and $70. The bank lowered the EPS estimate for Sigma for full-year 2011 to $3.76 from $3.77. The lower estimates reflect a challenging academic funding environment as well as European macro-environment, an analyst said in a research note.

CLC Bio this week that its operating profit rose more than 50 percent for 2011, year over year, and its software sales increased 30 percent. CEO Thomas Knudsen said its annual profit for the year was more than $1 million.

Exiqon has launched its 2012 research grant program. The program has been seeded with $40,000 and will provide grants to research projects "enhancing the understanding of how microRNA expression and function relates to normal cellular development, and/or disease-related cellular pathways," the firm said in a statement.

Adaptive TCR has changed its name to Adaptive Biotechnologies. The Seattle-based firm makes next-generation sequencing-based assays for the adaptive immune system.

Evogene this week said that it has created a wholly owned subsidiary called Evofuel focused on developing seeds for feedstock that can be used as biofuel.

In Brief This Week is a Friday column containing news items that our readers may have missed during the week.

The Scan

Transcriptomic, Epigenetic Study Appears to Explain Anti-Viral Effects of TB Vaccine

Researchers report in Science Advances on an interferon signature and long-term shifts in monocyte cell DNA methylation in Bacille Calmette-Guérin-vaccinated infant samples.

DNA Storage Method Taps Into Gene Editing Technology

With a dual-plasmid system informed by gene editing, researchers re-wrote DNA sequences in E. coli to store Charles Dickens prose over hundreds of generations, as they recount in Science Advances.

Researchers Model Microbiome Dynamics in Effort to Understand Chronic Human Conditions

Investigators demonstrate in PLOS Computational Biology a computational method for following microbiome dynamics in the absence of longitudinally collected samples.

New Study Highlights Role of Genetics in ADHD

Researchers report in Nature Genetics on differences in genetic architecture between ADHD affecting children versus ADHD that persists into adulthood or is diagnosed in adults.