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One of the variants leads to increased phosphorylation of a signaling pathway as well as to increased cell proliferation, hinting at how it contributes to disease risk.

Individuals with higher-than-usual mutant allele frequencies after stem cell transplantation were prone to disease progression and reduced progression-free survival.

Under the deal, Novacyt's Primerdesign business will work with Applied Microarrays on the development of microarray-based diagnostic assays.

The CPMC study aims to provide participants with their genetic and non-genetic risks for disease and drug response and monitor how their behaviors change.

The international team then used the approach to show that appropriate guide RNA design can reduce off-target effects of editing in mouse livers.

The researchers said their findings could help classify BRCA1 variants, particularly one whose impact on cancer risk is currently not clear.

Arbor will provide reagents to Tataa for its courses on next-generation sequencing applications, while Tataa will distribute Arbor's products in European countries.

Researchers found that the diverse features in mixed phenotype acute leukemia may stem from early blood progenitor mutations.

The firm will use the funds to advance its high-throughput single-cell analysis platform to analyze heterogeneity in cell populations for research and drug discovery.

The company said it will use the proceeds to develop new liquid biopsy tests to predict drug response in cancer patients.

The firm will sell more than 14 million shares of its common stock for $4.25 per share.

Premier is a healthcare group purchasing organization representing about 4,000 hospitals and 165,000 other providers throughout the US.

Individuals with northern genetic ancestry were buried with more grave goods than individuals with local southern genetic ancestry, the researchers found.

UMich's Arul Chinnaiyan plans to use the funding to develop new tools and technologies to identify biomarkers for cancer diagnosis and treatment.

An analysis on thousands of Japanese individuals with autism spectrum disorder or schizophrenia uncovered shared pathways and an abundance of rare exonic copy number variants.

A new study shows that DNA targets bound by nucleosomes are cleaved less efficiently than targets lacking nucleosomes, which could inform target selection.

With their strategic partnership, the bioinformatics firms seek to "break the biomarker bottleneck" that is holding back the potential of multi-omics research.

The companies initially expect to incorporate a CDx for Incyte's pemigatinib into Foundation Medicine's existing FDA-approved assay, FoundationOne CDx.

The firm did not disclose how many shares it planned to sell or how much money it expects to raise.

Expedeon's colloidal gold is an aqueous suspension of uniform, spherical metallic nanoparticles that can conjugate to antibodies and antigens.

The court upheld a judgement of no interference-in-fact from the Patent Trial and Appeal Board, leaving the Broad in control of key CRISPR IP.

CHOP's Gabriella Miller Kids First Pediatric Data Resource Center will use PhenoTips software from Gene42 to integrate "deep phenotyping" with genomic data.

Using Hi-C, genome sequencing, and optical mapping, researchers profiled structural variants in multiple cancer cell lines, leading to potential non-coding drivers.

Merck will use Definiens' web-based collaboration software platform alongside Definiens' image-analysis technologies for biomarker quantification.

Last week, GenomeWeb's readers were most interested in Guardant Health's filing for a $100 million IPO.

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The New York Times and ProPublica look into the close relationship between a startup and Memorial Sloan Kettering Cancer Center.

Yahoo News reports millions of dollars are being transferred from NIH, CDC, and other programs to pay for the housing of detained undocumented immigrant children.

Researchers gave a handful of octopuses MDMA to find that they too act more social on the drug, Gizmodo reports.

In Science this week: in vitro generation of human reproductive cells, and more.