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Researchers concluded that there has been significant expansion of coverage for ctDNA assays over the past four years, but policies remain very heterogeneous and often limited.

Unlike previously described cytidine deaminases, this toxin catalyzes the deamination of cytidines within double-stranded DNA, the researchers said.

An analysis of more than 800 individuals uncovered evidence of an admixture event between Native Americans from present-day Colombia and Polynesians.

Researchers saw similar cell hierarchies and progenitor cell clusters when comparing single-cell RNA sequencing data for cells from glioblastoma tumors and developing brains.

Twist will give Takeda access to its phage display libraries to help Takeda discover and validate antibodies needed for the development of new biologics. 

The deal makes WuXi NextCode the exclusive provider of Olink's proteomics products in China, which the company will offer on a fee-for-service basis.

Laboratorio Clinico Toledo's test detects SARS-CoV-2 nucleic acid, while Assure Tech's test is designed to detect antibodies against the virus.

The companies will work together to bring Guardant360 through regulatory approval and commercialize it as a CDx for Janssen's amivantamab. 

The company said that it expects to post molecular diagnostics revenues of about $65 million, up more than 100 percent compared to Q2 2019.

Thermo Fisher has also applied to the Japanese Ministry of Health, Labor, and Welfare to expand the use of the Oncomine Dx Target test in Japan.

The firm anticipates that Q2 2020 revenues associated with its ePlex tests would increase by about 195 percent compared to Q2 2019.

A study of families from the Netherlands revealed a RIPOR2 deletion as a common cause for hearing loss, making it a unique target for gene therapy. 

Natera sued Progenity in June but the firm said its Innatal cell-free DNA noninvasive prenatal test does not infringe any of Natera's six patents.

The guidance suggests validating a five-sample pooling strategy, but notes that this may need to be adjusted depending on assay sensitivity and local prevalence.

Using computational modeling, researchers developed tools that they said will facilitate modeling and correction of genetic diseases by base editing. 

A Regeneron-led team identified four variants that affect LDL cholesterol levels and are much more prevalent among Southwestern American Indians.

The firm said its coronavirus assay targets the nucleocapsid and envelope virus genes and is compatible with most RNA extraction methods and qPCR instruments.

The initial investment is led by Debiopharm, which will collaborate with the Israeli startup to accelerate discovery of biomarkers for oncology drug response.

The gut microbiomes of Irish Travellers who switched from a nomadic to a settled lifestyle fell between those of people from industrialized and non-industrialized populations.

Abcam will develop custom protein-based reagents for targets identified by researchers funded by Cancer Research UK. 

Last week, GenomeWeb's readers were most interested in a study that compared the DNA methylomes of humans and dogs.

The combination flu and RSV assay can be used alone or in combination with the company's Simplexa COVID-19 Direct assay for SARS-CoV-2 infection.

The firm's revenues were stronger than expected, due primarily to demand for its COVID-19 molecular diagnostic and rapid immunoassay products.

The agency said it recommends that clinical laboratory staff and healthcare providers consider any positive result presumptive from the BD SARS-CoV-2 test.

The test can help diagnose spinal muscular atrophy and identify carriers without symptoms who may be at risk of passing the disease to their children.

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The US has sent its formal notice of withdrawal from the World Health Organization, according to the Wall Street Journal.

Science reports that a draft spending bill would increase the US National Institutes of Health budget by 13 percent.

The Harvard Crimson reports that Harvard and MIT are suing the Department of Homeland Security and ICE over the new international student visa policy.

In Nucleic Acids Research this week: algorithm to determine molecular sequence types and other microbial features, computational method to uncover R-loop structures, and more.