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You're Actually Supposed to Be Able to Do That?

A discussion is going on over at the DrugMonkey blog on the materials and methods sections of papers. "This stupid failure to actually publish the real methodology (yes, including how many times the prep failed before you lucked onto the one that worked and really don't know why!) wastes my taxpayer dollars," he writes, adding that page restrictions are a "lame excuse" for not publishing the real methodology. "I try to describe my Methods as completely as possible and never fear making it too easy for the competition," DrugMonkey writes.

The Scan

UCLA Team Reports Cost-Effective Liquid Biopsy Approach for Cancer Detection

The researchers report in Nature Communications that their liquid biopsy approach has high specificity in detecting all- and early-stage cancers.

Machine Learning Improves Diagnostic Accuracy of Breast Cancer MRI, Study Shows

Combining machine learning with radiologists' interpretations further increased the diagnostic accuracy of MRIs for breast cancer, a Science Translational Medicine paper finds.

Genome Damage in Neurons Triggers Alzheimer's-Linked Inflammation

Neurons harboring increased DNA double-strand breaks activate microglia to lead to neuroinflammation like that seen in Alzheimer's disease, a new Science Advances study finds.

Long COVID-19 Susceptibility Clues Contained in Blood Plasma Proteome

A longitudinal study in eBioMedicine found weeks-long blood plasma proteome shifts after SARS-CoV-2 infection, along with proteomic signatures that appeared to coincide with long Covid risk.