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Your Very Own Mouse Colony

As techniques have been refined, interest in personalized mouse models of disease has risen, writes Andrew Pollack at The New York Times. While the use of such avatars has not been proven to affect patient outcomes and is expensive, Pollack says that some cancer patients are still trying that approach to learn more about how their cancers, implanted into mice, react to different drugs. One such patient, Nir Toib, tells Pollack that the combination of drugs recommended by his mouse avatar results helped treat his lung cancer while those suggested by genetic testing of his tumor did not. "I had 10 tumors on my right kidney," Toib says. "All of them disappeared."

The Scan

Cell Signaling Pathway Identified as Metastasis Suppressor

A new study in Nature homes in on the STING pathway as a suppressor of metastasis in a mouse model of lung cancer.

Using Bees to Gain Insights into Urban Microbiomes

As bees buzz around, they pick up debris that provides insight into the metagenome of their surroundings, researchers report in Environmental Microbiome.

Age, Genetic Risk Tied to Blood Lipid Changes in New Study

A study appearing in JAMA Network Open suggests strategies to address high lipid levels should focus on individuals with high genetic risk and at specific ages.

Study Examines Insights Gained by Adjunct Trio RNA Sequencing in Complex Pediatric Disease Cases

Researchers in AJHG explore the diagnostic utility of adding parent-child RNA-seq to genome sequencing in dozens of families with complex, undiagnosed genetic disease.