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In Your Head

Two articles published in Nature Genetics found new gene variants associated with high body mass index and that appear to be active in the brain. The Genetic Investigation of Anthropometric Traits consortium did a meta-analysis of 15 genome-wide association studies to find six loci associated with obesity, many of which act in the central nervous system. Researchers led by Decode Genetics' Kari Stefansson performed a genome-wide association study of weight and body mass index, identifying 29 variants, seven of which had not been linked to obesity before. The British Heart Foundation's Peter Weissberg told the BBC, "It suggests that some people may be less able than others to resist the temptation to overeat because of their genetic background and it might start to explain why some people have no problem keeping their weight down whilst others struggle."

The Scan

Fertility Fraud Found

Consumer genetic testing has uncovered cases of fertility fraud that are leading to lawsuits, according to USA Today.

Ties Between Vigorous Exercise, ALS in Genetically At-Risk People

Regular strenuous exercise could contribute to motor neuron disease development among those already at genetic risk, Sky News reports.

Test Warning

The Guardian writes that the US regulators have warned against using a rapid COVID-19 test that is a key part of mass testing in the UK.

Science Papers Examine Feedback Mechanism Affecting Xist, Continuous Health Monitoring for Precision Medicine

In Science this week: analysis of cis confinement of the X-inactive specific transcript, and more.