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You Should Consider Modeling

Michael White has a post at Adaptive Complexity about the value of building mathematical models in understanding biological systems. "There is a big gap between biophysicists and physiologists - in the realm of molecular, cell, and developmental biology, the value of building mathematical models is not widely accepted," he writes, noting that part of the reason may be how much progress has been made in molecular biology without having to lean on such models. Still, he says, biologists would do well if they learned to love this approach. "Molecular biologists should care about mathematical models because it is only through such models that we can study dynamical properties, and dynamical properties are interesting and important," White adds.

The Scan

UK Pilot Study Suggests Digital Pathway May Expand BRCA Testing in Breast Cancer

A randomized pilot study in the Journal of Medical Genetics points to similar outcomes for breast cancer patients receiving germline BRCA testing through fully digital or partially digital testing pathways.

Survey Sees Genetic Literacy on the Rise, Though Further Education Needed

Survey participants appear to have higher genetic familiarity, knowledge, and skills compared to 2013, though 'room for improvement' remains, an AJHG paper finds.

Study Reveals Molecular, Clinical Features in Colorectal Cancer Cases Involving Multiple Primary Tumors

Researchers compare mismatch repair, microsatellite instability, and tumor mutation burden patterns in synchronous multiple- or single primary colorectal cancers.

FarGen Phase One Sequences Exomes of Nearly 500 From Faroe Islands

The analysis in the European Journal of Human Genetics finds few rare variants and limited geographic structure among Faroese individuals.