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You're Not Helping

President Obama has recently called for a three-year freeze of all US federal, non-military employee salaries. But Mike the Mad Biologist says all this will do is "make things worse for research in the US." NIH program officers are already overworked and there aren't enough people to get the work done, he says, so this move will make morale worse and make retaining good people even more difficult. And the president's decision is even worse in light of where the money's going, Mike adds — not to fund Pell Grants or build some "supertrains," but to "pay for wars we should not be fighting, and keep taxes low on the wealthy. ... Not hopey. Not at all."

The Scan

Transcriptomic, Epigenetic Study Appears to Explain Anti-Viral Effects of TB Vaccine

Researchers report in Science Advances on an interferon signature and long-term shifts in monocyte cell DNA methylation in Bacille Calmette-Guérin-vaccinated infant samples.

DNA Storage Method Taps Into Gene Editing Technology

With a dual-plasmid system informed by gene editing, researchers re-wrote DNA sequences in E. coli to store Charles Dickens prose over hundreds of generations, as they recount in Science Advances.

Researchers Model Microbiome Dynamics in Effort to Understand Chronic Human Conditions

Investigators demonstrate in PLOS Computational Biology a computational method for following microbiome dynamics in the absence of longitudinally collected samples.

New Study Highlights Role of Genetics in ADHD

Researchers report in Nature Genetics on differences in genetic architecture between ADHD affecting children versus ADHD that persists into adulthood or is diagnosed in adults.