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Yes, But Can They Drink Beer Like People?

Mice are an important tool in biomedical research, particularly when it comes to testing possible new drugs, says 80beats' Joseph Castro. But when it comes to testing drug side effects, they're not always accurate — mouse livers and human livers react differently to pharmaceutical compounds. But in a new study published in PNAS, researchers at MIT say they've found a solution, Castro says: implanting mice with miniature, humanized livers. The team first developed tissue scaffolds by combining hepatocytes with other mouse and human cells. Once the scaffolds were implanted into the mice's abdominal cavities, the livers took about a week to integrate fully into the mice, Castro says. In addition to more accurately predicting drug toxicity, the researchers think the new livers will help scientists find treatments for diseases like hepatitis C, which mice don't normally contract, he adds.

The Scan

Not Kept "Clean and Sanitary"

A Food and Drug Administration inspection uncovered problems with cross contamination at an Emergent BioSolutions facility, the Wall Street Journal reports.

Resumption Recommendation Expected

The Washington Post reports that US officials are expected to give the go-ahead to resume using Johnson & Johnson's SARS-CoV-2 vaccine.

Canada's New Budget on Science

Science writes that Canada's new budget includes funding for the life sciences, but not as much as hoped for investigator-driven research.

Nature Papers Examine Single-Cell, Multi-Omic SARS-CoV-2 Response; Flatfish Sequences; More

In Nature this week: single-cell, multi-omics analysis provides insight into COVID-19 pathogenesis, evolution of flatfish, and more.