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The X Chromosome in Africa

Brazilian biologists, in conjunction with the Institute of Human Genetics, Newcastle University, have performed a worldwide phylogeographical study of the X chromosome by examining a haplotype block on a region of X chromosome where recombination is rare. Their findings, published in PLoS One, support currently accepted theories of a single origin of modern humans in Africa within the last 195,000 years, as well as migration out of Africa about 55,000 to 65,000 years ago.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.