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Wikis All Around

In PLoS Biology, Andrew Su and his colleagues report that they have laid the foundation for creating a comprehensive gene wiki, similar to the recent WikiProteins but within the general Wikipedia community. The researchers hypothesized that creating stubs with low levels of information from authoritative sources, such as Entrez Gene, would accelerate the growth of the wiki. Su tells Agence France-Press that their goal was to provide a starting point and that it is up to other scientists to keep the gene entries up-to-date. Trey at Open Helix, however, is not convinced this crowd-sourcing approach will work. "Wikipedia is doing reasonably well in 'general science', but I’m not so sure the model will work for this kind of science," he blogs.

The Scan

Study Finds Sorghum Genetic Loci Influencing Composition, Function of Human Gut Microbes

Focusing on microbes found in the human gut microbiome, researchers in Nature Communications identified 10 sorghum loci that appear to influence the microbial taxa or microbial metabolite features.

Treatment Costs May Not Coincide With R&D Investment, Study Suggests

Researchers in JAMA Network Open did not find an association between ultimate treatment costs and investments in a drug when they analyzed available data on 60 approved drugs.

Sleep-Related Variants Show Low Penetrance in Large Population Analysis

A limited number of variants had documented sleep effects in an investigation in PLOS Genetics of 10 genes with reported sleep ties in nearly 192,000 participants in four population studies.

Researchers Develop Polygenic Risk Scores for Dozens of Disease-Related Exposures

With genetic data from two large population cohorts and summary statistics from prior genome-wide association studies, researchers came up with 27 exposure polygenic risk scores in the American Journal of Human Genetics.