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Whole-Genome Liability

As whole-genome sequencing becomes more common in the clinic, doctors may be facing the consequences of the technological shift, says this article at Slate from Future Tense's Gary Marchant and Rachel Lindor. Whole-genome sequencing opens up a number of liabilities for physicians, Marchant and Lindor say. For example, they write that even doctors who adopt whole-genome sequencing may face lawsuits if they do not recognize the significance of a variant or d not disclose medically relevant findings to patients' relatives. "Other dynamics of WGS will exacerbate these physician liability risks. There will be constant and rapid changes in our knowledge about the significance of various genetic variants, requiring doctors to constantly re-evaluate the diagnosis, prognosis, and treatment of their patients," Marchant and Lindor add.

The Scan

Study Reveals New Details About Genetics of Major Cause of Female Infertility

Researchers in Nature Medicine conducted a whole-exome sequencing study of mote than a thousand patients with premature ovarian insufficiency.

Circulating Tumor DNA Shows Potential as Biomarker in Rare Childhood Cancer

A study in the Journal of Clinical Oncology has found that circulating tumor DNA levels in rhabdomyosarcoma may serve as a biomarker for prognosis.

Study Recommends Cancer Screening for Dogs Beginning Age Seven, Depending on Breed

PetDx researchers report in PLOS One that annual cancer screening for dogs should begin by age seven.

White-Tailed Deer Harbor SARS-CoV-2 Variants No Longer Infecting Humans, Study Finds

A new study in PNAS has found that white-tailed deer could act as a reservoir of SARS-CoV-2 variants no longer found among humans.