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Whiter Whites and Abated Amplicon Contamination

Shoba Anantha at Bitesize Bio says that the most effective way the reduce amplicon contamination in labs running PCR is to "get the bleach out." She references a 1992 study by Andrus and Prince that reports a dilution of household bleach as more effective at destroying DNA detectable by PCR than 2.0 N HCl. Anantha suggests that a 10 to 100x dilution of commercial bleach, such as Clorox, should be used to wipe down every surface in the lab. "Generously spray workstations/equipment/pipettes with 10 percent bleach, then let it sit for 15-30 minutes (coffee break time!). Then wipe up the bleach and follow up with a water rinse and wipe," she says, adding that "this procedure should be carried [out] before and after each PCR, and definitely after a spill. I religiously stick to a weekly cleaning routine of all of my PCR equipment and workspace and that has gone a long way to preventing amplicon contamination."

The Scan

Billions for Antivirals

The US is putting $3.2 billion toward a program to develop antivirals to treat COVID-19 in its early stages, the Wall Street Journal reports.

NFT of the Web

Tim Berners-Lee, who developed the World Wide Web, is auctioning its original source code as a non-fungible token, Reuters reports.

23andMe on the Nasdaq

23andMe's shares rose more than 20 percent following its merger with a special purpose acquisition company, as GenomeWeb has reported.

Science Papers Present GWAS of Brain Structure, System for Controlled Gene Transfer

In Science this week: genome-wide association study ties variants to white matter stricture in the brain, and more.