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A Whirlwind of Genomics

The Biology of Genomes conference kicked off earlier this week in Cold Spring Harbor, NY. The Tuesday evening sessions focused on single-cell genomics, and Wednesday's sessions dived into complex traits and cancer.

On Wednesday morning, for example, Luke Jostins from the Wellcome Trust Sanger Institute presented new insights garnered from inflammatory bowel disease studies, both of Crohn's disease and colitis. Jostins and his colleagues analyzed 63,796 samples, in which they identified 193 associations, 92 of which were previously known, 68 of which were novel. Further, the team found that there is an overlap between genes and pathways involved in IBD and in immune response, particularly to mycobacterium infection.

In an evening session that same day, the University of Montreal's Julie Hussin presented a familial study of pediatric acute lymphoblastic leukemia, in which she and her colleagues examined an unusual pattern of recombination in the mother of an affected family. Hussin and her colleagues found that the mother had a rare PRDM9 allele. PRDM9 has been previously linked to genomic instablilty. Hussin and her colleagues later found other rare PRDM9 alleles in additional ALL families, she said.

Our sister publication GenomeWeb Daily News has more from Biology of Genomes.

The Scan

Billions for Antivirals

The US is putting $3.2 billion toward a program to develop antivirals to treat COVID-19 in its early stages, the Wall Street Journal reports.

NFT of the Web

Tim Berners-Lee, who developed the World Wide Web, is auctioning its original source code as a non-fungible token, Reuters reports.

23andMe on the Nasdaq

23andMe's shares rose more than 20 percent following its merger with a special purpose acquisition company, as GenomeWeb has reported.

Science Papers Present GWAS of Brain Structure, System for Controlled Gene Transfer

In Science this week: genome-wide association study ties variants to white matter stricture in the brain, and more.