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Which Comes First?

Razib Khan at Discover's Gene Expression blog says there is "a chicken-and-egg problem with personal genomics." More specifically, until sequencing personal genomes becomes ubiquitous and the process transparent, he says they will be somewhat of a "letdown in terms of what it can, or can't, tell us." At the same time, he adds, "as long as there’s a letdown, it won’t become ubiquitous and transparent." So, which will come first? Time will tell, Khan says. In the meantime, though, Khan says he chose to publicize his genotype information in order "to show people that there’s nothing terrifying about it. Once the fear is gone, we can move forward and get some work done."

The Scan

Transcriptomic, Epigenetic Study Appears to Explain Anti-Viral Effects of TB Vaccine

Researchers report in Science Advances on an interferon signature and long-term shifts in monocyte cell DNA methylation in Bacille Calmette-Guérin-vaccinated infant samples.

DNA Storage Method Taps Into Gene Editing Technology

With a dual-plasmid system informed by gene editing, researchers re-wrote DNA sequences in E. coli to store Charles Dickens prose over hundreds of generations, as they recount in Science Advances.

Researchers Model Microbiome Dynamics in Effort to Understand Chronic Human Conditions

Investigators demonstrate in PLOS Computational Biology a computational method for following microbiome dynamics in the absence of longitudinally collected samples.

New Study Highlights Role of Genetics in ADHD

Researchers report in Nature Genetics on differences in genetic architecture between ADHD affecting children versus ADHD that persists into adulthood or is diagnosed in adults.