A the end of the year or decade, most lists are of the best or greatest achievements of that time frame, but Scientific American takes a different tack by listing the "Ten Science Letdowns of the New Millennium." Among those 10 include: a lack of victory in the war on cancer, the brain remaining mostly mysterious, and including evolution in science classrooms still being a topic of debate.

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At his FDA Law Blog, Jeffrey Gibbs discusses FDA's technical assistance for the draft Diagnostic Accuracy and Innovation Act.

The New York Times reports that genetic testing has uncovered unfaithful penguins at a Utah aquarium.

Cancer researcher loses funding under new Wellcome Trust anti-bullying policies, the Guardian reports.

In Science this week: International Wheat Genome Sequencing Consortium publishes the bread wheat cultivar Chinese Spring reference genome, and more.