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When the Ugly Duckling Grew Up, It Was a Beautiful Swan (Or Therapeutic)

Over at In the Pipeline, Derek Lowe blogs about the outcome of all those compounds that are discovered but can't be used as therapeutics. After looking at a particular compound that will never be used as a therapeutic, he writes, "But all this brings up another thing that we were talking about around here -- how much do drug companies owe academia for working out fundamental biochemistry and molecular biology? What if someone uses this very compound, for example, as a research tool and discovers something about its target that could be used to develop an actual drug?" (If you're thinking that you deserve credit for establishing the foundational research that was used to create some blockbuster drug, fuhgeddaboudit.)

 

The Scan

Tens of Millions Saved

The Associated Press writes that vaccines against COVID-19 saved an estimated 20 million lives in their first year.

Supersized Bacterium

NPR reports that researchers have found and characterized a bacterium that is visible to the naked eye.

Also Subvariants

Moderna says its bivalent SARS-CoV-2 vaccine leads to a strong immune response against Omicron subvariants, the Wall Street Journal reports.

Science Papers Present Gene-Edited Mouse Models of Liver Cancer, Hürthle Cell Carcinoma Analysis

In Science this week: a collection of mouse models of primary liver cancer, and more.