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What's up with Nanopore Sequencing?

There hasn't been a peep out of Oxford Nanopore Technologies since the company announced in February that its DNA strand sequencing nanopore method is working and that it is developing it commercially. "When will nanopores actually hit the market?" asks Keith Robison at his Omics! Omics! blog.

A recent review article on nanopore sequencing by Meni Wanunu at Northeastern University questions "whether the remaining technical hurdles can be overcome to create a workable, easily produced commercial device," according to the publisher.

In a LinkedIn forum, DNA sequencing veteran Tim Hunkapillar ponders whether "it just may be that nanopore sequencers are the perpetual motion machines of our age."

But for Robison, "a more apt comparison would be to the world of nuclear power, and the question is whether nanopores are more akin to nuclear fission or nuclear fusion."

The Scan

Genes Linked to White-Tailed Jackrabbits' Winter Coat Color Change

Climate change, the researchers noted in Science, may lead to camouflage mismatch and increase predation of white-tailed jackrabbits.

Adenine Base Editor Targets SCID Mutation in New Study

Researchers from the University of California, Los Angeles, report in Cell that adenine base editing was able to produce functional T lymphocytes in a model of severe combined immune deficiency.

Researchers Find Gene Affecting Alkaline Sensitivity in Plants

Researchers from the Chinese Academy of Science have found a locus affecting alkaline-salinity sensitivity, which could aid in efforts to improve crop productivity, as they report in Science.

International Team Proposes Checklist for Returning Genomic Research Results

Researchers in the European Journal of Human Genetics present a checklist to guide the return of genomic research results to study participants.