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What Do You Mean, We Have to Ask for Permission?

Ever wonder what would happen if you skipped a step while doing your research? Prominent German anesthesiologist Joachim Boldt is facing just that problem, as he is being investigated for conducting research without first getting permission from the Institutional Review Board , says Pharmalot's Ed Silverman. Several journals are conducting further reviews as they contemplate whether to retract nearly 100 studies, Silverman says. One article, published in December 2009 in Anesthesia & Analgesia, was retracted in October 2010 after no evidence was found of any patient or lab data to suggest that the study was even performed, he adds. Steve Shafer, the editor of Anesthesia & Analgesia, called the situation "unglaublich" — German for "unbelievable" — and says the situation calls for a review of the rules of oversight of investigator-initiated trials, both in Germany and in other countries as well.

The Scan

Self-Reported Hearing Loss in Older Adults Begins Very Early in Life, Study Says

A JAMA Otolaryngology — Head & Neck Surgery study says polygenic risk scores associated with hearing loss in older adults is also associated with hearing decline in younger groups.

Genome-Wide Analysis Sheds Light on Genetics of ADHD

A genome-wide association study meta-analysis of attention-deficit hyperactivity disorder appearing in Nature Genetics links 76 genes to risk of having the disorder.

MicroRNA Cotargeting Linked to Lupus

A mouse-based study appearing in BMC Biology implicates two microRNAs with overlapping target sites in lupus.

Enzyme Involved in Lipid Metabolism Linked to Mutational Signatures

In Nature Genetics, a Wellcome Sanger Institute-led team found that APOBEC1 may contribute to the development of the SBS2 and SBS13 mutational signatures in the small intestine.