The Edge.org asks its annual question of "What will change everything: what game-changing scientific ideas and developments do you expect to live to see?" Eric Kandel hopes to see a biological understanding of mental illness; Ian Wilmut is looking for a change in healthcare due to molecular genetics and stem cell biology; Craig Venter says he is on the verge of being able to insert a synthetic chromosome into a cell; and Dean Ornish looks forward to personalized medicine though adds that lifestyle changes are important.