Over at In the Pipeline, Derek Lowe's reaction to a new McKinsey report on pharma's return on investment elicits this succinct response: "Yikes." According to the report, ROI from small-molecule drug research has dropped from 12 percent in the late '90s to about 7.5 percent this decade.

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Researchers hope to tease out the signature effects that different carcinogens leave on the genome to determine their contributions to disease, Mosaic reports.

The Wall Street Journal looks into the cost of new gene therapies.

An Imperial College London-led team reports that it was able to use a gene drive to control a population of lab mosquitos.

In PNAS this week: genomic effects of silver fox domestication, limited effect of mitochondrial mutations on aging in fruit flies, and more.