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Over at In the Pipeline, Derek Lowe's reaction to a new McKinsey report on pharma's return on investment elicits this succinct response: "Yikes." According to the report, ROI from small-molecule drug research has dropped from 12 percent in the late '90s to about 7.5 percent this decade.

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The World Health Organization will be providing low-cost COVID-19 tests to low- and middle-income nations, according to Reuters.

Nature News examines how the confirmation of Amy Coney Barrett to the US Supreme Court could affect scientific agencies.

Nobel Prize-winner Arthur Ashkin, who developed optical tweezers, has died at 98, the Washington Post reports.

In PNAS this week: altered gene expression in brain samples from Alzheimer's disease patients, effects of gene mutations found in bladder cancer, and more.