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This Week's Freebies in PNAS

A couple of open-access papers in the current issue of Proceedings of the National Academy of Sciences are particularly targeted for this community.

In a paper out of Ron Davis' lab at Stanford, the authors describe experiments using "a genome-wide assay for mapping introns in Saccharomyces cerevisiae" they developed with tiling arrays. The technique turned up previously undiscovered introns.

Another paper from the University of Lausanne reports on work from lead author Marta Fierro-Fernández and colleagues on their studies of supercoiling in bacterial DNA plasmids, from which the team posits that a particular topological effect "protects DNA molecules against extensive fork reversals," according to the abstract.


The Scan

Tens of Millions Saved

The Associated Press writes that vaccines against COVID-19 saved an estimated 20 million lives in their first year.

Supersized Bacterium

NPR reports that researchers have found and characterized a bacterium that is visible to the naked eye.

Also Subvariants

Moderna says its bivalent SARS-CoV-2 vaccine leads to a strong immune response against Omicron subvariants, the Wall Street Journal reports.

Science Papers Present Gene-Edited Mouse Models of Liver Cancer, Hürthle Cell Carcinoma Analysis

In Science this week: a collection of mouse models of primary liver cancer, and more.