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This Week in Science: Apr 27, 2007

We've got microRNAs galore in today's edition of Science.

A paper from Rooij et al. at the University of Texas Southwestern Medical Center used a cardiac-specific microRNA to show that the MHC gene regulates heart growth and stress-related gene expression.

Meanwhile, a paper out of Caltech (Chen et al.) looks at selfish elements in the Drosophila genome that rely on microRNAs to silence a particular gene for embryogenesis.

These papers, from Thai et al. at Harvard Medical School and from Rodriguez, Vigorito, et al. at Sanger and the Babraham Institute, describe the importance of a conserved microRNA in the mammalian immune system.

And if microRNAs aren't your thing, Ishii and colleagues from Keio University report on high-throughput, systems-level studies of genetic and environmental perturbations in E. coli. A perspective for this paper was written by Uwe Sauer et al. on the importance of full system views of organisms.

 

The Scan

Fertility Fraud Found

Consumer genetic testing has uncovered cases of fertility fraud that are leading to lawsuits, according to USA Today.

Ties Between Vigorous Exercise, ALS in Genetically At-Risk People

Regular strenuous exercise could contribute to motor neuron disease development among those already at genetic risk, Sky News reports.

Test Warning

The Guardian writes that the US regulators have warned against using a rapid COVID-19 test that is a key part of mass testing in the UK.

Science Papers Examine Feedback Mechanism Affecting Xist, Continuous Health Monitoring for Precision Medicine

In Science this week: analysis of cis confinement of the X-inactive specific transcript, and more.