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This Week in Science: Jul 4, 2008

The peer review process continues to have problems. In an editorial this week, Science editors discuss steps researchers and their organizations can take to improve the process. This letter from Martin Raff, Alexander Johnson, and Peter Walter suggests ways journal editors and reviewers can make peer review more efficient.

This news item reports on progress at the Cancer Genome Atlas pilot project, whose leaders presented updates on their work to NCI's scientific advisors last week. So far, the article says, presenters and advisors alike find the results promising.

A report from Michael Sanderson at the University of Arizona uses analysis of phylogenetic signals in sequences from GenBank to make the case that scientists will need to obtain gene sequence from many more organisms in order to build high-resolution phylogenetic trees on a broad scale.

This paper, from senior author Karel Svodoba at HHMI's Janelia Farm and Cold Spring Harbor Laboratory, demonstrates the results of two types of imaging to study the activity of Ras after being activated in a dendritic spine.

 

The Scan

Study Finds Few FDA Post-Market Regulatory Actions Backed by Research, Public Assessments

A Yale University-led team examines in The BMJ safety signals from the US FDA Adverse Event Reporting System and whether they led to regulatory action.

Duke University Team Develops Programmable RNA Tool for Cell Editing

Researchers have developed an RNA-based editing tool that can target specific cells, as they describe in Nature.

Novel Gene Editing Approach for Treating Cystic Fibrosis

Researchers in Science Advances report on their development of a non-nuclease-based gene editing approach they hope to apply to treat cystic fibrosis.

Study Tracks Responses in Patients Pursuing Polygenic Risk Score Profiling

Using interviews, researchers in the European Journal of Human Genetics qualitatively assess individuals' motivations for, and experiences with, direct-to-consumer polygenic risk score testing.