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This Week in Science: Mar 30, 2007

From the latest issue of Science:

A news item digs into the recent National Research Council report recommending a Global Metagenomics Initiative to better understand the microbial world through a mega-sequencing project.

A paper from lead authors Hang Yin and Joanna Slusky at the University of Pennsylvania discuss a new computational approach called CHAMP that allows users to design peptides that target specific transmembrane helices.

Also from U Penn, Joonil Jung and Nancy Bonini publish work using a Drosophila model for CAG/polyglutamine disease spinocerebellar ataxia type 3, through which they witnessed traits common to human CAG-repeat instability. They posit that "toxic consequences of pathogenic polyQ protein may include enhancing repeat instability."

From the Children's Medical Research Institute and lead author Scott Cohen comes a paper on the composition of telomerase by purifying it and performing mass spec sequencing to determine protein components and molecular size.


The Scan

mRNA-Based Vaccine on the Way in China

China may soon have its own mRNA-based vaccine, according to Nature News.

Arranged Killing, Fraud Alleged by Prosecutors

The Wall Street Journal reports that prosecutors allege that the co-founder of a biotech arranged to have a business associate who threatened to expose him as a fraud killed.

Whirlwind Decade of CRISPR

The New York Times looks back at the 10 years since the University of California, Berkeley's Jennifer Doudna and her colleagues published their CRISPR paper.

PNAS Papers on Blue Cone Monochromacy Structural Variants, HIV-1 Mutant, T-ALL

In PNAS this week: structural variants linked to blue cone monochromacy, HIV-1 variants affecting the matrix protein p17, and more.