This Week in Science

In Science this week, a team of UK scientists report the discovery of multiple proteins responsible for the disassembly of the replisome, the structure responsible for synthesizing complementary DNA strands during chromosome replication. They showed that a ubiquitin ligase promotes ubiquitylation of CMG, the ring-shaped DNA helicase that unwinds DNA at the start of replication. Another protein complex then associates with the ubiquitylated CMG, leading rapidly to helicase disassembly.

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The UK's Nuffield Council on Bioethics says genetically modifying human embryos could be morally permissible, according to the Guardian.

A new Nature Biotechnology paper reports that CRISPR-Cas9 gene editing can lead to large deletions or complex rearrangements that could be pathogenic.

The Wall Street Journal likens a prototype developed by Synthetic Genomics to a "biological fax machine."

In PNAS this week: strategy for reactivating Rett syndrome-linked MECP2, small molecules able to suppress Staphylococcus aureus virulence, and more.