This Week in Science

In this week's Science, a team led by researchers from Montana State University publish the crystal structure of the CRISPR RNA-guided surveillance complex in Escherichia coli. CRISPR is part of an adaptive immune system in bacteria and is being adapted as a research tool and potential therapeutic. In E. coli, CRISPR-derived RNAs form a protein complex known as Cascade that helps detect invading DNA.

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Researchers hope to tease out the signature effects that different carcinogens leave on the genome to determine their contributions to disease, Mosaic reports.

The Wall Street Journal looks into the cost of new gene therapies.

An Imperial College London-led team reports that it was able to use a gene drive to control a population of lab mosquitos.

In PNAS this week: genomic effects of silver fox domestication, limited effect of mitochondrial mutations on aging in fruit flies, and more.