This Week in Science

In this week's Science, a multi-institute team of researchers report on the discovery that a specific mutation that causes nerve cell death only functions in the presence of a second mutation, offering insights into how a person's genetic makeup can influence disease development. In mouse experiments, the scientists found that the loss of a specific protein involved in the ribosome recycling led to ribosome stalling and widespread neurodegeneration, but only in one particular genetic background.

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