This Week in Science

In this week's Science, a multi-institute team of researchers report on the discovery that a specific mutation that causes nerve cell death only functions in the presence of a second mutation, offering insights into how a person's genetic makeup can influence disease development. In mouse experiments, the scientists found that the loss of a specific protein involved in the ribosome recycling led to ribosome stalling and widespread neurodegeneration, but only in one particular genetic background.

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In Science this week: mtDNA analysis give glimpse into decline of Neanderthals in Europe, and more.

The University of Arizona's Raina Maier writes that an understanding of the Earth's microbiome is needed.

The proposed Canadian budget emphasizes partnerships with industry, Nature News reports.

An Australian study of personalized medicine has run into problems as it recruits patients.