This Week in Science

In this week's Science, a group led by University College London researchers report on a new gene therapy approach that combines optogenetics and embryonic stem cell-based regenerative medicine, and which was used to restore skeletal muscle function in injured and diseased mice. The scientists engineered ESC-derived motor neurons to express the light-sensitive ion channel known as channelrhodopsin-2 and grafted them onto the ligated sciatic nerves in the animals.

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