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In today's Science, proteins rule. A paper out of Jonathan Lin's lab at UCSF looks at the unfolded protein response as a result of stress at the endoplasmic reticulum. Of the three intracellular signaling branches, IRE1 plays a key role in promoting cell survival; and it, along with ATF6, another signaling branch, are turned off after prolonged ER stress.

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The UK and the European Union have come to a sticking point in the negotiation of how the UK might remain involved in the Horizon Europe research program, the Guardian reports.

The New York Times reports that experts pushed during a meeting of an FDA advisory board for the agency to require more safety data from SARS-CoV-2 vaccine trials.

The Washington Post reports Moderna expects that it will have enough data on its candidate SARS-CoV-2 vaccine to submit to regulatory authorities by mid-November.

In Science this week: ANXA11 variants affect calcium homeostasis and stress granule disassembly in ALS, and more.