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This Week in Science: Nov 9, 2007

In today's Science, proteins rule. A paper out of Jonathan Lin's lab at UCSF looks at the unfolded protein response as a result of stress at the endoplasmic reticulum. Of the three intracellular signaling branches, IRE1 plays a key role in promoting cell survival; and it, along with ATF6, another signaling branch, are turned off after prolonged ER stress.

Researchers at Pitt's Biomedical Science Tower have determined the functional link between Rheb and mTOR, which has implications in signaling disregulation in cancers. Finding that Rheb regulates mTOR through FKBP38, they conclude that FKBP38 is an endogenous inhibitor of mTOR, which is antagonized by Rheb in response to growth factor stimulation and nutrient availability.

Cold Spring Harbor and SUNY Stony Brook researchers used proton nuclear magnetic resonance spectroscopy to identify and characterize a metabolic biomarker that allows the detection and quantification of neural progenitor or stem cells in the human brain in vivo. An in-depth news piece focuses on the benefits for research of human brain disorders.



The Scan

Billions for Antivirals

The US is putting $3.2 billion toward a program to develop antivirals to treat COVID-19 in its early stages, the Wall Street Journal reports.

NFT of the Web

Tim Berners-Lee, who developed the World Wide Web, is auctioning its original source code as a non-fungible token, Reuters reports.

23andMe on the Nasdaq

23andMe's shares rose more than 20 percent following its merger with a special purpose acquisition company, as GenomeWeb has reported.

Science Papers Present GWAS of Brain Structure, System for Controlled Gene Transfer

In Science this week: genome-wide association study ties variants to white matter stricture in the brain, and more.